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There really is no difference. For almost all intents and purposes, GOG’s offline installers can be treated the same way as physical CDs of way back then, with one of the only exceptions being that you cannot resell them.
Depending on your perspective, the sell/trade/loan aspect of physical can be a huge deal. I outlined in another comment, selling/trading games was never my thing, but it was my cousins. From my perspective, there’s marginal difference, but there IS a difference.