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Well, yes. But I would argue that if you have the skills to defeat eg. the Draconic Sentinel with just two runes, then it’s probably not your first rodeo. Stumbling over all the steps to eg. Varre or Hyettas quests on an unguided playthrough, which require specific things in a certain order in a huge world, are not particularly likely either. Its size works against it in that regard.
Doing it in NG+ isn’t that difficult at all since you already have your stats set and multiple weapons maxed out.