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Quite a lot of the Indiana Jones stories are based on real, or at least “real” artifacts.
Ark of the Covenant:
https://en.m.wikipedia.org/wiki/Ark_of_the_Covenant
Lingam Stones:
https://en.m.wikipedia.org/wiki/Lingam
Holy Grail:
https://en.m.wikipedia.org/wiki/Holy_Grail
Crystal Skulls:
https://en.m.wikipedia.org/wiki/Crystal_skull
Antikythera Mechanism:
https://en.m.wikipedia.org/wiki/Antikythera_mechanism
Another one that popped up in Dial of Destiny was the Spear of Longinus:
https://en.m.wikipedia.org/wiki/Holy_Lance