Technically, yes. WINE/Proton aren’t sandboxed so it would be possible to pull some information at least. I’ve heard people install the flatpak version of Steam to isolate network calls using flatseal, so that’s one workaround potentially.
NOTE: I’m just talking about generic data collection. The DRM/anti-cheat stuff could flag you as using Linux and then the game just refuses to run. I know the new ToS talked about banning VMs so maybe they lump linux users into that (at least for online play).
YT performance videos show Witcher 3 running at 60FPS on Steamdeck and Arkham Knight averages around 53-55FPS on Steamdeck. Side by side comparison videos of Witcher 3 show Steamdeck has higher graphical fidelity over Switch 2 as well.