Factorio was inspired by Minecraft mods BuildCraft and IndustrialCraft, but yeah, few games have done what Factorio has, and those that have tried never quite reached it’s level. Sure, there are games that feature automation with complex recipes (Satisfactory, Dyson Sphere Program, Shapez), but only Factorio actually managed to pull off a sense of exponential scale.
There’s no big reason why remapping couldn’t be done in a way that doesn’t require actively running software on the host machine. QMK, the open source firmware for keyboards has had this for years. You can update your keymap with an online editor, but once it’s flashed, your mappings will be remembered regardless of which computer/phone/whatever you use the keyboard with - without having to run any software besides the OS on the host.